The Big Fix (1978) — pool man
French Postcards (1979) — Sayyid
Last Embrace (1979) — first commuter
Night of the Juggler (1980) — Allesandro the cabbie
Ragtime (1981) — Tateh
Yentl (1983) — Avigdor
Daniel (1983) — Paul Isaacson
Maxie (1985) — Nick
Tenkû no shiro Rapyuta (1986) (voice: English version) — Louis
The Princess Bride (1987) — Inigo Montoya
Alien Nation (1988) — Detective Samuel 'George' Francisco
The House on Carroll Street (1988) — Ray Salwen
Dick Tracy (1990) — 88 Keys
True Colors (1991) — John Palmeri
Impromptu (1991) — Alfred De Musset
The Doctor (1991) — Dr. Murray Kaplan
The Music of Chance (1993) — Jim Nashe
Life with Mikey (1993) — irate man
Squanto: A Warrior's Tale (1994) — Brother Daniel
The Hunchback (TV version) (1997) — Quasimodo
Lulu On The Bridge (1998) — Philip Kleinman
Men with Guns (1998) — Andrew
The Adventures of Elmo in Grouchland (1999) — Huxley
Piñero (2001) — Joseph Papp
Run Ronnie Run (2002) — as himself, portraying Ronnie Dobbs, in an in-movie stage performance
The Choking Man (2005); Rick
Everyone's Hero (2006) (voice) — Stanley Irving
Television
Patinkin as "Rube" in Dead Like Me.That Thing on ABC — (1978), performer
Charleston — (1979), Beaudine Croft
Sunday in the Park with George — (1986), Georges Seurat/George
Chicago Hope — Dr. Jeffrey Geiger (Emmy Award, 1994-95)
Dead Like Me — Rube John Sofer
The Larry Sanders Show — Himself
Law & Order — Levi March in "Absentia" (Saison 13, episode 290)
The Simpsons — Hugh Parkfield in "Lisa's Wedding" (Saison 6, episode 619)
Touched By An Angel — Satan in Netherlands (single-episode guest star) (Saison 7, episode 23)
The Hunchback of Notre Dame (1996)
Broken Glass (1996) — Dr. Harry Hyman
Strange Justice (1999) — Kenneth Duberstein
NTSB: The Crash of Flight 323 (2004) — Al Cummings
Criminal Minds — (2005-2007) Jason Gideon
Television commercials
7 Up (1970)
Frosted Mini-Wheats (1971) (the first Kellogg's Frosted Mini-Wheats commercial)
Procrit (approx. 2001)
Crestor (2005)